TY  - JOUR
AB  - Peritonsillar abscess (PTA) is a very frequent reason for urgent outpatient consultation and otolaryngological hospital admission. Early, correct diagnosis and therapy of peritonsillar abscess are important to prevent possible life-threatening complications. Based on physical examinations, a reliable differentiation between peritonsillar cellulitis and peritonsillar abscess is restricted. A heterodimeric complex called calprotectin consists of the S100 proteins A8 and A9 (S100A8/A9) and is predominantly expressed not only in monocytes and neutrophils but also in epithelial cells. Due to its release by activated phagocytes at local sites of inflammation, we assumed S100A8/A9 to be a potential biomarker for peritonsillar abscess. We examined serum and saliva of patients with peritonsillitis, acute tonsillitis, peritonsillar abscess, and healthy controls and found significantly increased levels of S100A8/A9 in patients with PTA. Furthermore, we could identify halitosis, trismus, uvula edema, and unilateral swelling of the arched palate to be characteristic symptoms for PTA. Using a combination of these characteristic symptoms and S100A8/A9 levels, we developed a PTA score as an objective and appropriate tool to differentiate between peritonsillitis and peritonsillar abscess with a sensitivity of 92% and specificity of 93%.
AU  - Spiekermann, Christoph Otto
AU  - Spiekermann, Christoph O.
AU  - Spiekermann, C. O.
AU  - Russo, Antonella
AU  - Stenner, Markus
AU  - Rudack, Claudia
AU  - Roth, Johannes
AU  - Vogl, Thomas
DA  - 2017-10-17
DO  - 10.1155/2017/9126560
LA  - eng
N1  - Disease Markers (2017) Article ID 912656, 1-10
N1  - Finanziert durch den Open-Access-Publikationsfonds 2017 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2017-10-17
TI  - Increased Levels of S100A8/A9 in Patients with Peritonsillar Abscess: A New Promising Diagnostic Marker to Differentiate between Peritonsillar Abscess and Peritonsillitis
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-77159467058
Y2  - 2024-11-22T06:38:09
ER  -