TY  - JOUR
AB  - In Alzheimer´s disease (AD), persistent microglial activation as sign of chronic neuroinflammation contributes to disease progression. Our study aimed to in vivo visualize and quantify microglial activation in 13- to 15-month-old AD mice using [11C]-(R)-PK11195 and positron emission tomography (PET). We attempted to modulate neuroinflammation by subjecting the animals to an anti-inflammatory treatment with pioglitazone (5-weeks’ treatment, 5-week wash-out period). [11C]-(R)-PK11195 distribution volume values in AD mice were significantly higher compared with control mice after the wash-out period at 15 months, which was supported by immunohistochemistry data. However, [11C]-(R)-PK11195 μPET could not demonstrate genotype- or treatment-dependent differences in the 13- to 14 month-old animals, suggesting that microglial activation in AD mice at this age and disease stage is too mild to be detected by this imaging method.
AU  - Rapic, Sara
AU  - Backes, Heiko
AU  - Viel, Thomas
AU  - Monfared, Parisa
AU  - Parisa Monfared
AU  - Jacobs, Andreas H.
AU  - Kummer, Markus Peter
AU  - Neumaier, Bernd
AU  - Vollmar, Stefan
AU  - Hoehn, Mathias
AU  - Van der Linden, Annemie
AU  - Heneka, Michael Thomas
AU  - Heneka, Michael Thomas Johannes
DA  - 2012
KW  - Alzheimer’s  disease
KW  - Inflammation
KW  - Microglia
KW  - Molecular Imaging
KW  - Positron emission tomography
KW  - PK11195
KW  - PPAR-gamma
KW  - Transgenic mice
LA  - eng
N1  - This is a pre-print version. A definitive version was subsequently published in
Neurobiol Aging, 2012 May 29 [Epub ahead of print], 
DOI: 10.1016/j.neurobiolaging.2012.04.016
PY  - 2012
TI  - Imaging microglial activation and glucose consumption in a mouse model of Alzheimer’s disease
TT  - Darstellung von Mikrogliaaktivierung und Glukoseverbrauch in einem Maus Modell für Morbus Alzheimer
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-10419426271
Y2  - 2024-11-22T03:36:03
ER  -