TY  - JOUR
AB  - Limbic hyperactivation and an impaired functional interplay between the amygdala and the prefrontal cortex are discussed to go along with, or even cause, pathological anxiety. Within the multi-faceted group of anxiety disorders, the highly prevalent social phobia (SP) is characterized by excessive fear of being negatively evaluated. Although there is widespread evidence for amygdala hypersensitivity to emotional faces in SP, verbal material has rarely been used in imaging studies, in particular with an eye on disorder-specificity. Using functional magnetic resonance imaging (fMRI) and a block design consisting of (1) overall negative, (2) social-phobia related, (3) positive, and (4) neutral words, we studied 25 female patients with social phobia and 25 healthy female control subjects (HC). Results demonstrated amygdala hyperactivation to disorder-relevant but not to generally negative words in SP patients, with a positive correlation to symptom severity. A functional connectivity analysis revealed a weaker coupling between the amygdala and the left middle frontal gyrus in patients. Symptom severity was negatively related to connectivity strength between the amygdala and the ventromedial prefrontal and orbitofrontal cortex (Brodmann Area 10 and 11). The findings clearly support the view of a hypersensitive threat-detection system, combined with disorder-related alterations in amygdala-prefrontal cortex connectivity in pathological anxiety.
AU  - Laeger, Inga Brit
AU  - Radenz, Britta
AU  - Arolt, Volker
AU  - Arolt, V.
AU  - Dannlowski, Udo
AU  - Zwanzger, Peter M.
AU  - Dobel, Christian
AU  - Keuper, Katharina
AU  - Eden, Annuschka Salima
AU  - Kugel, Harald
AU  - Zwitserlood, Pienie
DA  - 2014-11-14
DO  - doi:10.1371/journal.pone.0109949
LA  - eng
N1  - PLoS ONE 9 (2014) 11, 1-10, e109949
N1  - Finanziert durch den Open-Access-Publikationsfonds 2014/2015 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2014-11-14
SN  - 1932-6203
TI  - Of ‘Disgrace’ and ‘Pain’ – Corticolimbic Interaction Patterns for Disorder-Relevant and Emotional Words in Social Phobia
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-11319584896
Y2  - 2024-11-21T22:03:33
ER  -