TY  - JOUR
AB  - Background: Previous studies have reported white matter (WM) brain alterations in asymptomatic patients with human immunodeficiency virus (HIV). Methods: We compared diffusion tensor imaging (DTI) derived WM fractional anisotropy (FA) between HIV-patients with and without mild macroscopic brain lesions determined using standard magnetic resonance imaging (MRI). We furthermore investigated whether WM alterations co-occurred with neurocognitive deficits and depression. We performed structural MRI and DTI for 19 patients and 19 age-matched healthy controls. Regionally-specific WM integrity was investigated using voxel-based statistics of whole-brain FA maps and region-of-interest analysis. Each patient underwent laboratory and neuropsychological tests. Results: Structural MRI revealed no lesions in twelve (HIV-MRN) and unspecific mild macrostructural lesions in seven patients (HIV-MRL). Both analyses revealed widespread FA-alterations in all patients. Patients with HIV-MRL had FA-alterations primarily adjacent to the observed lesions and, whilst reduced in extent, patients with HIV-MRN also exhibited FA-alterations in similar regions. Patients with evidence of depression showed FA-increase in the ventral tegmental area, pallidum and nucleus accumbens in both hemispheres, and patients with evidence of HIV-associated neurocognitive disorder showed widespread FA-reduction. Conclusion: These results show that patients with HIV-MRN have evidence of FA-alterations in similar regions that are lesioned in HIV-MRL patients, suggesting common neuropathological processes. Furthermore, they suggest a biological rather than a reactive origin of depression in HIV-patients.
AU  - Dräger, Bianca
AU  - Deppe, Michael
AU  - Mohammadi, Siawoosh
AU  - Keller, Simon S.
AU  - Kugel, Harald
AU  - Grégor, Nora
AU  - Evers, Stefan
AU  - Young, Peter
AU  - Ringelstein, Erich B.
AU  - Arendt, Gabriele
AU  - Arendt, G.
DA  - 2012-05-01
DO  - doi:10.1186/1471-2377-12-23
KW  - Depression
KW  - HIV-associated neurocognitive disorder
KW  - Fractional anisotropy
KW  - Neuropsychology
LA  - eng
N1  - Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
N1  - BMC Neurology 12 (2012) 23
PY  - 2012-05-01
TI  - Early microstructural white matter changes in patients with HIV: A diffusion tensor imaging study
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-47369468214
Y2  - 2024-11-21T16:38:05
ER  -