TY  - JOUR
AB  - Background: The overexpression of tumor necrosis factor (TNF)-α leads to systemic as well as local loss of bone and cartilage and is also an important regulator during fracture healing. In this study, we investigate how TNF-α inhibition using a targeted monoclonal antibody affects fracture healing in a TNF-α driven animal model of human rheumatoid arthritis (RA) and elucidate the question whether enduring the anti TNF-α therapy after trauma is beneficial or not. Methods: A standardized femur fracture was applied to wild type and human TNF-α transgenic mice (hTNFtg mice), which develop an RA-like chronic polyarthritis. hTNFtg animals were treated with anti-TNF antibody (Infliximab) during the fracture repair. Untreated animals served as controls. Fracture healing was evaluated after 14 and 28 days of treatment by clinical assessment, biomechanical testing and histomorphometry. Results: High levels of TNF-α influence fracture healing negatively, lead to reduced cartilage and more soft tissue in the callus as well as decreased biomechanical bone stability. Blocking TNF-α in hTNFtg mice lead to similar biomechanical and histomorphometrical properties as in wild type. Conclusions: High levels of TNF-α during chronic inflammation have a negative impact on fracture healing. Our data suggest that TNF-α inhibition by an anti-TNF antibody does not interfere with fracture healing.
AU  - Timmen, Melanie
AU  - Hidding, Heriburg
AU  - Wieskötter, Britta
AU  - Baum, Wolfgang
AU  - Pap, Thomas
AU  - Raschke, Michael J.
AU  - Schett, Georg
AU  - Zwerina, Jochen
AU  - Stange, Richard
DA  - 2014-05-29
DO  - doi:10.1186/1471-2474-15-184
KW  - Anti-TNFα
KW  - Inflammation
KW  - Fracture healing
KW  - Rheumatoid arthritis
KW  - Treatment
LA  - eng
N1  - BMC Musculoskeletal Disorders 15 (2014) 184, 1-6
N1  - Finanziert durch den Open-Access-Publikationsfonds 2014/2015 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2014-05-29
SN  - 1471-2474
TI  - Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-91339470608
Y2  - 2024-11-22T08:05:17
ER  -