TY  - JOUR
AB  - Background: Perioperative chemotherapy increases the overall and progression-free survival of patients suffering from resectable adenocarcinomas of the lower esophagus, gastroesophageal junction and stomach (GEC). Comparing different chemotherapy regimens platin-based protocols with 5-fluorouracil (5-FU)/calcium folinate (CF) or oral fluoropyrimidines were favorable in terms of efficacy and side-effects. However, there is no consensus which regimen is the most efficacious. Methods: 42 consecutive patients with resectable GEC (UICC II and III) were treated with 3 pre- and postoperative chemotherapy cycles each consisting of epirubicin, oxaliplatin and capecitabine (EOX). We analyzed the overall survival, progression-free survival and toxicity retrospectively in comparison to published data. Results: The median overall survival in our cohort was 29 months and the progression-free survival was 17 months. The most frequent grade 3 and 4 toxicities during preoperative chemotherapy were diarrhea (16.7%), leukocytopenia (9.5%) and nausea (9.5%); overall 38.1% of our patients suffered from grade 3 or 4 toxicity. Surgery was carried out in 83% of our patients, 69% of those achieved R0 resection. Conclusion: Comparing our data with the results of previously published randomized trials EOX is at least non-inferior with regard to overall survival, progression-free survival and toxicity. In conclusion, EOX is an appropriate perioperative therapy for patients with resectable GEC.
AU  - Brehler, Ann-Christin
AU  - Hartmann, Wolfgang
AU  - Wiebe, Stefanie
AU  - Nolting, Stefanie
AU  - Kerkhoff, Andrea
AU  - Schliemann, Christoph
AU  - Palmes, Daniel Michael
AU  - Senninger, Norbert
AU  - Lenze, Frank
AU  - Ullerich, Hansjörg
AU  - Ullerich, Hansjörg Detlef
AU  - Berdel, Wolfgang E.
AU  - Berdel, Wolfgang
AU  - Berdel, W. E.
AU  - Keßler, Torsten
DA  - 2015-04-09
DO  - 10.1371/journal.pone.0122974
LA  - eng
N1  - PLoS ONE 10 (2015) 4, e0122974, 1-11
N1  - Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2015-04-09
SN  - 1932-6203
TI  - Perioperative Chemotherapy in Gastroesophageal Cancer. A Retrospective Monocenter Evaluation of 42 Cases
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-07299570939
Y2  - 2024-11-22T02:21:01
ER  -