TY  - JOUR
AB  - In jawed vertebrates, the adaptive immune system (AIS) cooperates with the innate immune system (IIS) to protect hosts from infections. Although targeting non-self-components, the AIS also generates self-reactive antibodies which, when inadequately counter-selected, can give rise to autoimmune diseases (ADs). ADs are on the rise in western countries. Why haven’t ADs been eliminated during the evolution of a ∼500 million-year old system? And why have they become more frequent in recent decades? Self-recognition is an attribute of the phylogenetically more ancient IIS and empirical data compellingly show that some self-reactive antibodies, which are classifiable as elements of the IIS rather then the AIS, may protect from (rather than cause) ADs. Here, we propose that the IIS’s self-recognition system originally fathered the AIS and, as a consequence of this relationship, its activity is dampened in hygienic environments. Rather than a mere breakdown or failure of the mechanisms of self-tolerance, ADs might thus arise from architectural constraints.
AU  - Bayersdorf, Robert
AU  - Fruscalzo, Arrigo
AU  - Catania, Francesco
DA  - 2018-01-12
DO  - 10.1093/emph/eoy001
KW  - adaptive immune system
KW  - innate immune system
KW  - natural autoantibodies
KW  - self-recognition
KW  - pregnancy
KW  - immune tolerance
LA  - eng
N1  - Evolution, Medicine, and Public Health 2018 (2018) 1, 2-12
N1  - Finanziert durch den Open-Access-Publikationsfonds 2018 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2018-01-12
TI  - Linking autoimmunity to the origin of the adaptive immune system
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-15169570498
Y2  - 2024-11-22T04:19:15
ER  -