TY  - JOUR
AB  - Objectives: PSMA (prostate-specific membrane antigen) is overexpressed in prostate cancer cells and is reported to be a promising target for antibody-based radioligand therapy in patients with metastasized prostate cancer. Since PSMA expression is not restricted to prostate cancer, the underlying study investigates PSMA expression in non-small cell lung cancer (NSCLC). Material and methods: Immunohistochemistry was used to identify PSMA expression in n = 275 samples of NSCLC tissue specimens. By means of CD34 co-expression, the level of PSMA expression in tumor associated neovasculature was investigated. The impact of PSMA expression on clinicopathologic parameters and prognosis was evaluated. Results: PSMA tumor cell expression in NSCLC is as low as 6% and was predominantly found in squamous cell carcinoma (p = 0.002). Neovascular PSMA expression was found in 49% of NSCLC. High neovascular PSMA expression was associated with higher tumor grading (G3/G4) (p < 0.001). Neither for PSMA tumor cell expression, nor for PSMA neovascular cell expression prognostic effects were found for the investigated NSCLC cases. Conclusion: Here, we report on the expression of PSMA in NSCLC tissue samples. Against the background of a potential treatment with radiolabeled PSMA ligands, our data might serve for the future identification of patients who could benefit from this therapeutic option.
AU  - Schmidt, Lars Henning
AU  - Heitkötter, Birthe Franziska
AU  - Schulze, Arik Bernard
AU  - Schliemann, Christoph
AU  - Steinestel, Konrad Ernst
AU  - Trautmann, Marcel
AU  - Marra, Alessandro
AU  - Hillejan, Ludger
AU  - Mohr, Michael
AU  - Evers, Georg Heribert
AU  - Wardelmann, Eva
AU  - Rahbar, Kambiz
AU  - Görlich, Dennis
AU  - Lenz, Georg
AU  - Berdel, Wolfgang E.
AU  - Berdel, Wolfgang
AU  - Berdel, W. E.
AU  - Hartmann, Wolfgang
AU  - Wiewrodt, Rainer Gerhard
AU  - Wiewrodt, Rainer
AU  - Huss, Sebastian
DA  - 2017-10-27
DO  - 10.1371/journal.pone.0186280
LA  - eng
N1  - PLoS ONE 12 (2017) 10, e0188262, 1-12
N1  - Finanziert durch den Open-Access-Publikationsfonds 2018 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2017-10-27
TI  - Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-45159558749
Y2  - 2024-11-22T02:28:48
ER  -