TY  - JOUR
AB  - BACKGROUND: This retrospective, multicenter study aimed to reveal risk predictors for mortality in the intensive care unit (ICU) as well as survival after ICU discharge in patients with acute myeloid leukemia (AML) requiring treatment in the ICU. METHODS AND RESULTS: Multivariate analysis of data for 187 adults with AML treated in the ICU in one institution revealed the following as independent prognostic factors for death in the ICU: arterial oxygen partial pressure below 72 mmHg, active AML and systemic inflammatory response syndrome upon ICU admission, and need for hemodialysis and mechanical ventilation in the ICU. Based on these variables, we developed an ICU mortality score and validated the score in an independent cohort of 264 patients treated in the ICU in three additional tertiary hospitals. Compared with the Simplified Acute Physiology Score (SAPS) II, the Logistic Organ Dysfunction (LOD) score, and the Sequential Organ Failure Assessment (SOFA) score, our score yielded a better prediction of ICU mortality in the receiver operator characteristics (ROC) analysis (AUC = 0.913 vs. AUC = 0.710 [SAPS II], AUC = 0.708 [LOD], and 0.770 [SOFA] in the training cohort; AUC = 0.841 for the developed score vs. AUC = 0.730 [SAPSII], AUC = 0.773 [LOD], and 0.783 [SOFA] in the validation cohort). Factors predicting decreased survival after ICU discharge were as follows: relapse or refractory disease, previous allogeneic stem cell transplantation, time between hospital admission and ICU admission, time spent in ICU, impaired diuresis, Glasgow Coma Scale <8 and hematocrit of ≥25% at ICU admission. Based on these factors, an ICU survival score was created and used for risk stratification into three risk groups. This stratification discriminated distinct survival rates after ICU discharge. CONCLUSIONS: Our data emphasize that although individual risks differ widely depending on the patient and disease status, a substantial portion of critically ill patients with AML benefit from intensive care.
AU  - Pohlen, Michéle Yvonne
AU  - Pohlen, Michéle
AU  - Thoennißen, Nils Heinrich
AU  - Braess, Jan
AU  - Thudium, Johannes
AU  - Schmid, Christoph
AU  - Kochanek, Matthias
AU  - Kochanek, Matthias Hubertus
AU  - Kreuzer, Karl-Anton
AU  - Lebiedz, Pia
AU  - Görlich, Dennis
AU  - Gerth, Hans Ulrich
AU  - Gerth, Hans Ulrich Volker
AU  - Gerth, Hans U.
AU  - Rohde, Christian
AU  - Keßler, Torsten
AU  - Müller-Tidow, Carsten
AU  - Stelljes, Matthias
AU  - Büchner, Thomas
AU  - Schlimok, Günter
AU  - Hallek, Michael
AU  - Waltenberger, Johannes
AU  - Hiddemann, Wolfgang
AU  - Hiddemann, W.
AU  - Berdel, Wolfgang E.
AU  - Berdel, Wolfgang
AU  - Berdel, W. E.
AU  - Heilmeier, Bernhard
AU  - Krug, Utz
DA  - 2016-08-30
DO  - 10.1371/journal.pone.0160871
LA  - eng
N1  - PLoS ONE 11 (2016) 8, e0160871, 1-16
N1  - Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster)
PY  - 2016-08-30
SN  - 1932-6203
TI  - Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-83269517453
Y2  - 2024-11-22T01:05:45
ER  -