TY  - JOUR
AB  - We synthesised and toxicologically characterised the arsenic metabolite thiodimethylarsinic acid (thio-DMAV). Successful synthesis of highly pure thio-DMAV was confirmed by state-of-the-art analytical techniques including 1H-NMR, HPLC-FTMS, and HPLC-ICPMS. Toxicological characterization was carried out in comparison to arsenite and its well-known trivalent and pentavalent methylated metabolites. It comprised cellular bioavailability as well as different cytotoxicity and genotoxicity end points in cultured human A549 lung cells. Of all arsenicals investigated, thio-DMAV exerted the strongest cytotoxicity. Moreover, thio-DMAV did not induce DNA strand breaks and an increased induction of both micronuclei and multinucleated cells occurred only at beginning cytotoxic concentrations, indicating that thio-DMAV does not act via a genotoxic mode of action. Finally, to assess potential implications of thio-DMAV for human health, further mechanistic studies are urgently necessary to identify the toxic mode of action of this highly toxic, unusual pentavalent organic arsenical.
AU  - Bartel, Marc
AU  - Ebert, Franziska
AU  - Klauer, Franziska
AU  - Klauer, Franziska
AU  - Leffers, Larissa
AU  - Karst, Uwe
AU  - Schwerdtle, Tanja
DA  - 2011
DO  - 10.1155/2011/37314
LA  - eng
N1  - Finanziert durch den Open-Access-Publikationsfonds 2011/2012 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
N1  - Journal of Toxicology 2011 (2011) 373141
PY  - 2011
TI  - Toxicological Characterization of the Inorganic and Organic Arsenic Metabolite Thio-DMAV in Cultured Human Lung Cells
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-87379477683
Y2  - 2024-11-22T09:08:31
ER  -