TY  - JOUR
AB  - Molecular imaging techniques such as single photon emission computed tomography (SPECT) or positron emission tomography are promising tools for noninvasive diagnosis of acute allograft rejection (AR). Given the importance of renal transplantation and the limitation of available donors, detailed analysis of factors that affect transplant survival is important. Episodes of acute allograft rejection are a negative prognostic factor for long-term graft survival. Invasive core needle biopsies are still the “goldstandard” in rejection diagnostics. Nevertheless, they are cumbersome to the patient and carry the risk of significant graft injury. Notably, they cannot be performed on patients taking anticoagulant drugs. Therefore, a noninvasive tool assessing the whole organ for specific and fast detection of acute allograft rejection is desirable. We herein review SPECT- and PET-based approaches for noninvasive molecular imaging-based diagnostics of acute transplant rejection.
AU  - Pawelski, Helga
AU  - Schnöckel, Uta
AU  - Kentrup, Dominik
AU  - Kentrup, Dominik Richard
AU  - Grabner, Alexander
AU  - Schäfers, Michael
AU  - Reuter, Stefan Johannes
DA  - 2014-04-01
DO  - 10.1155/2014/874785
LA  - eng
N1  - Biomed Research International (2014) 874785, 7
N1  - Finanziert durch den Open-Access-Publikationsfonds 2013/2014 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2014-04-01
SN  - 2314-6141
TI  - SPECT- and PET-Based Approaches for Noninvasive Diagnosis of Acute Renal Allograft Rejection
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-24209573503
Y2  - 2024-11-22T03:39:30
ER  -