TY  - JOUR
AB  - Background: Littoral cell angioma (LCA) is a rare vascular tumor of the spleen. Generally thought to be benign, additional cases of LCA with malignant features have been described. Thus, its malignant potential seems to vary and must be considered uncertain. The etiology remains unclear, but an immune dysregulation for the apparent association with malignancies of visceral organs or immune-mediated diseases has been proposed. Case Presentation: We report a case of LCA in a 43-year old male patient who presented with a loss of appetite and intermittent upper abdominal pain. Computed tomography showed multiple hypoattenuating splenic lesions which were hyperechogenic on abdominal ultrasound. Lymphoma was presumed and splenectomy was performed. Pathological evaluation revealed LCA. Conclusions: LCA is a rare, primary vascular neoplasm of the spleen that might etiologically be associated with immune dysregulation. In addition, it shows a striking association with synchronous or prior malignancies. With about one-third of the reported cases to date being co-existent with malignancies of visceral organs or immunemediated diseases, this advocates for close follow-ups in all patients diagnosed with LCA. To our knowledge, this report is the first one of LCA associated with previous pulmonary sarcoidosis and hypothesizes a TNF-a related pathogenesis of this splenic tumor.
AU  - Cordesmeyer, Stefanie
AU  - Pützler, Manfred
AU  - Titze, Ulf
AU  - Paulus, Harald
AU  - Hoffmann, Matthias W.
DA  - 2011-09-19
DO  - doi:10.1186/1477-7819-9-106
KW  - Splenic tumor
KW  - littoral cell angioma
KW  - visceral organ malignancies
KW  - sarcoidosis
KW  - TNF-α
LA  - eng
N1  - Finanziert durch den Open-Access-Publikationsfonds 2011/2012 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
N1  - World Journal of Surgical Oncology 9 (2011) 106
PY  - 2011-09-19
TI  - Littoral cell angioma of the spleen in a patient with previous pulmonary sarcoidosis: a TNF-a related pathogenesis?
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-67389439408
Y2  - 2024-11-22T07:07:51
ER  -