TY  - THES
A3  - Vestweber, Dietmar
AB  - The role of L-selectin in the pathogenesis of EAE is still not clarified and previous investigations were not conclusive. To address whether L-selectin is involved in the development of EAE, SJL/L-sel-/- mice were generated backcrossing L-selectin-deficient mice into the SJL mouse strain. EAE was induced by active immunization with proteolipid protein (PLP). SJL wt and SJL/L-sel-/- mice had indistinguishable EAE symptoms and in brain of EAE affected mice CD45 + cell infiltrates were detected. EAE by adoptive transfer of in vitro activated PLP-specific T cell blasts was also induced, and in both strains EAE symptoms were scored and was possible to detect CD45+ cell infiltrates in brain and spinal cord. The migration efficiency of SJL wt and SJL/L-sel-/- T cells across the endothelium was evaluated by a functional assay. Taken together, it is possible to conclude that L-selectin is not involved in the recruitment of encephalitogenic cells across the BBB and in the pathogenesis of EAE in SJL mice.
AU  - Uboldi, Chiara
DA  - 2006
KW  - Autoimmunity
KW  - L-selectin
KW  - Adhesion molecules
KW  - CD4 positive cells
KW  - Demyelination
LA  - eng
PY  - 2006
TI  - SJL/L-selectin-deficient mice develop experimental autoimmune encephalomyelitis
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-71689574882
Y2  - 2024-11-22T03:52:23
ER  -