TY  - JOUR
AB  - Amputation often leads to painful phantom sensations, whose pathogenesis is still unclear. Supported by experimental findings, an explanatory model has been proposed that identifies maladaptive reorganization of the primary somatosensory cortex (S1) as a cause of phantom pain. However, it was recently found that BOLD activity during voluntary movements of the phantom positively correlates with phantom pain rating, giving rise to a model of persistent representation. In the present study, we develop a physiologically realistic, computational model to resolve the conflicting findings. Simulations yielded that both the amount of reorganization and the level of cortical activity during phantom movements were enhanced in a scenario with strong phantom pain as compared to a scenario with weak phantom pain. These results suggest that phantom pain, maladaptive reorganization, and persistent representation may all be caused by the same underlying mechanism, which is driven by an abnormally enhanced spontaneous activity of deafferented nociceptive channels.
AU  - Boström, Kim
AU  - Boström, Kim Joris
AU  - Boström, K. J.
AU  - Lussanet, Marc H. E. de
AU  - Weiß, Thomas
AU  - Weiß, T.
AU  - Puta, Christian
AU  - Wagner, Heiko
DA  - 2014-06-16
DO  - doi:10.1038/srep05298
KW  - Computational models
KW  - Network models
KW  - Chronic pain
KW  - Somatosensory system
LA  - eng
N1  - Scientific Reports 4 (2014) 5298, 1-9
N1  - Finanziert durch den Open-Access-Publikationsfonds 2014/2015 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2014-06-16
SN  - 2045-2322
TI  - A computational model unifies apparently contradictory findings concerning phantom pain
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-91339564480
Y2  - 2024-12-26T17:05:12
ER  -