TY  - JOUR
AB  - BACKGROUND: Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. Therefore, the aim of this study was to assess predictors and risk factors for HCC recurrence after LT in patients within and outside the Milan criteria with a special focus on the impact of different bridging strategies. METHODS: All patients who underwent LT for HCC between 07/2002 and 09/2016 at the University Hospital of Muenster were consecutively included in this retrospective study. Database research was performed and a multivariable regression analysis was conducted to explore potential risk factors for HCC recurrence. RESULTS: A total of 82 patients were eligible for the statistical analysis. Independent of bridging strategy, achieving complete remission (CR) was significantly associated with a lower risk for tumor recurrence (p = 0.029; OR = 0.426, 95% CI 0.198-0.918). A maximal diameter of lesion < 3 cm was also associated with lower recurrence rates (p = 0.040; OR = 0.140, 95% CI 0.022-0.914). Vascular invasion proved to be an independent risk factor for HCC recurrence (p = 0.004; OR = 11.357, 95% CI 2.142-60.199). CONCLUSION: Achieving CR prior to LT results in a significant risk reduction of HCC recurrence after LT independent of the treatment modalities applied.
AU  - Bürger, Christin
AU  - Maschmeier, Miriam
AU  - Hüsing-Kabar, Anna
AU  - Wilms, Christian
AU  - Köhler, Michael
AU  - Schmidt, Martina
AU  - Schmidt, Hartmut
AU  - Kabar, Iyad
DA  - 2019-01-08
DO  - 10.1155/2019/5796074
LA  - eng
N1  - Canadian Journal of Gastroenterology and Hepatology 2019 (2019), 5796074, 1-7
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2019-01-08
TI  - Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-32159598834
Y2  - 2024-11-21T18:16:11
ER  -