TY  - JOUR
AB  - Animals are inhabited by a diverse community of microorganisms. The relevance of such microbiota is increasingly being recognized across a broad spectrum of species, ranging from sponges to primates, revealing various beneficial roles that microbes can play. The red flour beetle Tribolium castaneum represents a well-established experimental model organism for studying questions in ecology and evolution, however, the relevance of its microbial community is still largely unknown. T. castaneum larvae orally exposed to bacterial components of the entomopathogen Bacillus thuringiensis bv. tenebrionis showed increased survival upon a subsequent challenge with spores of this bacterium. To investigate whether T. castaneum microbiota plays a role in this phenomenon, we established a protocol for raising microbe-free larvae and subsequently tested whether they differ in their ability to mount such a priming response. Here we demonstrate that larvae with significantly lowered microbial loads, show decreased survival upon secondary challenge with B. thuringiensis bv. tenebrionis spores, compared to animals that were allowed to regain their microbiota before priming. Although the exact mechanism of oral immune priming is unclear, we here suggest that microbiota plays a crucial role in oral immune priming in this species.
AU  - Futo, Momir
AU  - Armitage, Sophie A. O.
AU  - Kurtz, Joachim
DA  - 2016-01-06
DO  - 10.3389/fmicb.2015.01383
KW  - microbiota
KW  - oral infection
KW  - immune priming
KW  - innate immunity
KW  - Tribolium castaneum
KW  - Bacillus thuringiensis
LA  - eng
N1  - Frontiers in Microbiology 6 (2016) 1383, 1-10
N1  - Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2016-01-06
SN  - 1664-302X
TI  - Microbiota plays a role in oral immune priming in Tribolium castaneum
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-86229642556
Y2  - 2024-11-22T01:54:12
ER  -