TY  - JOUR
AB  - Amoebozoans are in many aspects interesting research objects, as they combine features of single-cell organisms with complex signaling and defense systems, comparable to multicellular organisms. 'Acanthamoeba castellanii' is a cosmopolitan species and developed diverged feeding abilities and strong anti-bacterial resistance; 'Entamoeba histolytica' is a parasitic amoeba, who underwent massive gene loss and its genome is almost twice smaller than that of 'A. castellanii'. Nevertheless, both species prosper, demonstrating fitness to their specific environments. Here we compare transcriptomes of 'A. castellanii' and 'E. histolytica' with application of orthologs' search and gene ontology to learn how different life strategies influence genome evolution and restructuring of physiology. 'A. castellanii' demonstrates great metabolic activity and plasticity, while 'E. histolytica' reveals several interesting features in its translational machinery, cytoskeleton, antioxidant protection, and nutritional behavior. In addition, we suggest new features in 'E. histolytica' physiology that may explain its successful colonization of human colon and may facilitate medical research.
AU  - Shabardina, Victoria
AU  - Kischka, Tabea
AU  - Kmita, Hanna
AU  - Suzuki, Yutaka
AU  - Makałowski, Wojciech
DA  - 2018-02-12
DO  - 10.7150/ijbs.23869
KW  - Life strategy
KW  - genomic adaptation
KW  - comparative genomics
KW  - Acanthamoeba castellanii
KW  - Entamoeba histolytica
LA  - eng
N1  - International Journal of Biological Sciences 14 (2018) 3, 306-320
N1  - Finanziert durch den Open-Access-Publikationsfonds 2018 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2018-02-12
TI  - Environmental adaptation of 'Acanthamoeba castellanii' and 'Entamoeba histolytica' at genome level as seen by comparative genomic analysis
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-45159505614
Y2  - 2024-11-22T03:31:24
ER  -