TY  - JOUR
AB  - Objectives: Tonsillectomy (TE) and tonsillotomy (TO) due to recurrent episodes of acute tonsillitis (RAT) belong to the most frequent surgical procedures. However, an adequate objective marker predicting the outcome of TE/TO preoperatively is missing. Methods: Patients with RAT who underwent TE/TO (n = 31) were included in this pilot study. A panel of cytokines and chemokines in serum and saliva were determined preoperatively. Health-related quality of life was assessed pre- and postoperatively by the Tonsillectomy Outcome Inventory-14. Results: Health-related quality of life improved significantly after surgery. Increased serum levels of interleukin-8 (IL-8) and interferon gamma (IFN-γ) are associated with a less successful outcome. No correlation between the number of acute tonsillitis episodes and the health-related quality of life after TE or TO could be observed. Conclusions: Tonsillectomy and TO improve health-related quality of life independently from the number of past acute tonsillitis episodes. Interleukin-8 and IFN-γ in serum may serve as promising markers, predicting the benefit of TE or TO for patients preoperatively.
AU  - Seethaler, Alicia
AU  - Stenner, Markus
AU  - McNally, Annika
AU  - Rudack, Claudia
AU  - Roth, Johannes
AU  - Vogl, Thomas
AU  - Spiekermann, Christoph Otto
AU  - Spiekermann, Christoph O.
AU  - Spiekermann, C. O.
DA  - 2020-03-17
KW  - tonsillectomy
KW  - tonsillotomy
KW  - cytokines
KW  - alarmins
KW  - outcome
KW  - biomarker
LA  - eng
N1  - Ear, Nose & Throat Journal 100 (2021) 5,  Suppl., 822S-827S
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2020-03-17
TI  - IL-8 and IFN-γ as Preoperative Predictors of the Outcome of Tonsillectomy
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-15069454674
Y2  - 2024-11-21T22:42:18
ER  -