TY  - JOUR
AB  - Influenza virus is a well-known respiratory pathogen, which still leads to many severe pulmonary infections in the human population every year. Morbidity and mortality rates are further increased if virus infection coincides with co-infections or superinfections caused by bacteria such as Streptococcus pneumoniae (S. pneumoniae) and Staphylococcus aureus (S. aureus). This enhanced pathogenicity is due to complex interactions between the different pathogens and the host and its immune system and is mainly governed by altered intracellular signaling processes. In this review, we summarize the recent findings regarding the innate and adaptive immune responses during co-infection with influenza virus and S. pneumoniae or S. aureus, describing the signaling pathways involved and how these interactions influence disease outcomes.
AU  - Wilden, Janine J.
AU  - Jacob, Jasmin C.
AU  - Ehrhardt, Christina
AU  - Ludwig, Stephan
AU  - Börgeling, Yvonne
DA  - 2021-05-22
DO  - 10.3390/ijms22115486
KW  - influenza virus
KW  - S. pneumoniae
KW  - S. aureus
KW  - immune response
LA  - eng
N1  - International Journal of Molecular Sciences 22 (2021) 11, 5486, 1-16
N1  - This work was supported by the German Research Foundation (SFB 1009, project B02—07/2012) and the Leibniz Association Science Campus “InfectoOptics” (PNEUTHERA—09/2019).
PY  - 2021-05-22
TI  - Altered Signal Transduction in the Immune Response to Influenza Virus and S. pneumoniae or S. aureus Co-Infections
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-37039664416
Y2  - 2024-11-21T23:20:31
ER  -