TY  - JOUR
AB  - Total body irradiation is an effective conditioning modality before autologous or allogeneic stem cell transplantation. With the whole body being the radiation target volume, a diverse spectrum of toxicities has been reported. This fact prompted us to investigate the long-term sequelae of this treatment concept in a large patient cohort. Overall, 322 patients with acute leukemia or myelodysplastic syndrome with a minimum follow-up of one year were included (the median follow-up in this study was 68 months). Pulmonary, cardiac, ocular, neurological and renal toxicities were observed in 23.9%, 14.0%, 23.6%, 23.9% and 20.2% of all patients, respectively. The majority of these side effects were grades 1 and 2 (64.9–89.2% of all toxicities in the respective categories). The use of 12 Gray total body irradiation resulted in a significant increase in ocular toxicities (p = 0.013) and severe mucositis (p < 0.001). Renal toxicities were influenced by the age at transplantation (relative risk: 1.06, p < 0.001) and disease entity. In summary, total body irradiation triggers a multifaceted, but manageable, toxicity profile. Except for ocular toxicities and mucositis, a 12 Gray regimen did not lead to an increase in long-term side effects.
AU  - Oertel, Michael
AU  - Martel, Jonas
AU  - Mikesch, Jan-Henrik
AU  - Scobioala, Sergiu
AU  - Reicherts, Christian
AU  - Kröger, Kai Jannes
AU  - Lenz, Georg
AU  - Stelljes, Matthias
AU  - Eich, Hans-Theodor
AU  - Eich, Hans Theodor
AU  - Eich, Hans Theodor
AU  - Eich, Hans Theodor
DA  - 2021-11-11
KW  - survivorship
KW  - TBI
KW  - long-term toxicity
KW  - leukemia
LA  - eng
N1  - Cancers 13 (2021) 22, 5640, 1-12
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2021-11-11
TI  - The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-55069466155
Y2  - 2024-11-22T03:06:39
ER  -