TY  - JOUR
AB  - The ventromedial prefrontal cortex (vmPFC) is a major hub of the reward system and has been shown to activate specifically in response to pleasant / rewarding stimuli. Previous studies demonstrate enhanced pleasant cue reactivity after single applications of transcranial direct current stimulation (tDCS) to the vmPFC. Here we present a pilot case study in which we assess the cumulative impact of multiple consecutive vmPFC-tDCS sessions on the processing of visual emotional stimuli in an event-related MEG recording design. The results point to stable modulation of increased positivity biases (pleasant > unpleasant stimulus signal strength) after excitatory vmPFC stimulation and a reversed pattern (pleasant < unpleasant) after inhibitory stimulation across five consecutive tDCS sessions. Moreover, cumulative effects of these emotional bias modulations were observable for several source-localized spatio-temporal clusters, suggesting an increase in modulatory efficiency by repeated tDCS sessions. This pilot study provides evidence for improvements in the effectiveness and utility of a novel tDCS paradigm in the context of emotional processing.
AU  - Winker, Constantin
AU  - Rehbein, Maimu Alissa Rhea
AU  - Sabatinelli, Dean
AU  - Junghöfer, Markus
DA  - 2020-01-21
DO  - 10.1371/journal.pone.0222057
LA  - eng
N1  - PLoS ONE 15 (2020) 1, e0222057, 1-11
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster)
N1  - This work was funded by the Interdisciplinary Center for Clinical Research of the University of Muenster (Ju2/024/15) and the Collaborative Research Center (SFB-TRR58/C08).
N1  - All MEG data and results files are available from the OSF database (URL: osf.io/8e6rf).
PY  - 2020-01-21
TI  - Repeated noninvasive stimulation of the ventromedial prefrontal cortex reveals cumulative amplification of pleasant compared to unpleasant scene processing: A single subject pilot study
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-37039527239
Y2  - 2024-11-22T02:18:31
ER  -