TY  - JOUR
AB  - Background: To evaluate safety and clinical outcome of repeated transarterial 90Y (yttrium) radioembolization (TARE) in primary and metastatic liver cancer. Methods: Between 2009 and 2018, n=288 patients underwent TARE for treatment of malignant liver disease in a tertiary care hospital. This retrospective single center study analyzed the safety and outcome of patients (n=11/288) undergoing repeated resin microsphere TARE. Included patients suffered from hepatocellular carcinoma (n=3), colorectal cancer (n=2), breast cancer (n=2), intrahepatic cholangiocarcinoma (n=3), and neuroendocrine carcinoma (n=1). All patients had shown either partial response (n=9) or stable disease (n=2) after first TARE. Lab parameters, response assessed by the Response Evaluation Criteria in Solid Tumors (mRECIST/RECIST) at 3 months and overall survival was analyzed. Additionally, patients with repeated TARE were compared to a matched control group (n=56) with single TARE therapy. Kaplan Meier analysis was performed to analyze survival. Results: Patients after repeated TARE showed similar increase in lab parameters as compared to their first TARE. No case of radioembolization induced liver disease was observed. While n=5/11 patients showed a partial response and n=4/11 patients a stable disease after repeated TARE, only n=2/11 patients suffered from progressive disease. Median overall survival was 20.9±11.9 months for the repeated TARE group while it was 5.9±16.2 months for the control group.Conclusions: Repeated 90Y TARE is safe and can be of benefit for patients yielding a comparable degree of local disease control compared to patients with singular TARE.
AU  - Masthoff, Max
AU  - Schindler, Philipp
AU  - Harders, Fabian
AU  - Heindel, Walter
AU  - Wilms, Christian
AU  - Schmidt, Hartmut
AU  - Pascher, Andreas
AU  - Stegger, Lars
AU  - Rahbar, Kambiz
AU  - Wildgruber, Moritz
AU  - Köhler, Michael
DA  - 2020-04-27
DO  - 10.17879/54039506101
KW  - Repeated radioembolization
KW  - 90Y yttrium
KW  - liver cancer
LA  - eng
N1  - Annals of Translational Medicine 8 (2020) 17, 1055, 1-8
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2020-04-27
TI  - Repeated radioembolization in advanced liver cancer
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-44039568194
Y2  - 2024-11-22T03:26:29
ER  -