TY  - JOUR
AB  - 'Helicobacter pylori' infection is associated with different gastric diseases, notably gastric cancer. The present study is aimed at comparing the effectiveness of various 'H. pylori' eradication regimens among adult and pediatric patients. A total of 3178 (396 children) patients were recruited. 'H. pylori' infection was diagnosed by nuclear stable isotopic 13C urea breath test (UBT) and positive patients were randomly allocated first-line eradication regimens. The second or third-line regimens were assigned to those who had failed first-line treatment. A negative UBT at least 4 weeks after the completion of treatment indicated a successful eradication of 'H. pylori'. Eradication rates (ER) by per-protocol (PP) and intention-to-treat (ITT) analysis were recorded. The overall prevalence of 'H. pylori' infection was 61.2% and slightly higher in males as compared to females. The modified concomitant therapy showed higher PP (77.8%) and ITT (72.7%) ER as first-line treatment. Among second-line therapies, PP/ITT ER of 63.6% / 55.3% were observed for quadruple therapy in adults. Standard triple therapy with probiotic and modified concomitant therapy as first-line and quadruple therapy as a second line thus is the choice for 'H. pylori' eradication in adult gastric disease patients. In pediatric patients, standard triple therapy was more effective as a first-line with about 68.8% ER.
AU  - Aziz, Shahid
AU  - Ali, Mashhood
AU  - Hussain, Mulazim
AU  - Javed, Anum
AU  - Fatima, Ayesha
AU  - Zehra, Tehzeeb
AU  - Rashid, Faizan
AU  - ur Rehman, Toufeeq
AU  - Faryal, Rani
AU  - Zahra, Rabaab
AU  - Ahmad, Tanvir
AU  - König, Simone
AU  - Rasheed, Faisal
DA  - 2022
DO  - 10.17879/22049740551
KW  - Helicobacter
KW  - Ausrottung
KW  - Antibiotika
KW  - Harnstoff-Atemtest
KW  - eradication
KW  - antibiotics
KW  - urea breath test
LA  - eng
IS  - Mercator Journal of Biomolecular Analysis
M2  - 1
PY  - 2022
SP  - 1-9
T2  - Mercator Journal of Biomolecular Analysis
TI  - Update on the eradication of 'Helicobacter pylori' infection in adult and pediatric patients from the northern region of Pakistan
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-92039600661
Y2  - 2024-11-22T02:02:06
ER  -