TY  - JOUR
AB  - Successful studies on radiation therapy for gastric lymphoma led to a decrease in planning target volume (PTV) and radiation dose with low toxicities, maintaining excellent survival rates. It remains unclear as to which effects are to be expected concerning dose burden on organs at risk (OAR) by decrease in PTV vs. dose and whether a direct impact on toxicity might be expected. We evaluated 72 radiation plans, generated prospectively for a cohort of 18 patients who were treated for indolent gastric lymphoma in our department. As a prospective work, four radiation plans with different radiation doses and target volumes (40 Gy-involved field, 40 Gy-involved site, 30 Gy-involved field, 30 Gy-involved site) were generated for each patient. Mean dose burden on adjacent organs was compared between the planning groups. Cohort toxicity data served to estimate parameters for the Lyman–Kutcher–Burman (LKB) model for normal tissue complication probability (NTCP). These were used to anticipate adverse events for OAR. Literature parameters were used to estimate high-grade toxicities of OAR. Decrease of dose and/or PTV led to median dose reductions between 0.13 and 5.2 Gy, with a significant dose reduction on neighboring organs. Estimated model parameters for liver, spleen, and bowel toxicity were feasible to predict cohort toxicities. NTCP for the endpoints elevated liver enzymes, low platelet count, and diarrhea ranged between 15.9 and 22.8%, 27.6 and 32.4%, and 21.8 and 26.4% for the respective four plan variations. Field and dose reduction highly impact dose burden and NTCP for OAR during stomach radiation. Our estimated LKB model parameters offer a good approximation for low-grade toxicities in abdominal organs with modern radiation techniques.
AU  - Reinartz, Gabriele Andrea Christiane
AU  - Baehr, Andrea
AU  - Kittel, Christopher
AU  - Oertel, Michael
AU  - Haverkamp, Uwe
AU  - Haverkamp, U.
AU  - Eich, Hans-Theodor
AU  - Eich, Hans Theodor
AU  - Eich, Hans Theodor
AU  - Eich, Hans Theodor
DA  - 2021-03-19
DO  - 10.17879/12099543334
KW  - NTCP
KW  - LKB model
KW  - side effects
KW  - radiation oncology
KW  - non-Hodgkin lymphoma
KW  - gastric lymphoma
LA  - eng
N1  - Cancers 13 (2021) 6, 1390, 1-13
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2021-03-19
TI  - Biophysical Analysis of Acute and Late Toxicity of Radiotherapy in Gastric Marginal Zone Lymphoma—Impact of Radiation Dose and Planning Target Volume
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-52089546863
Y2  - 2024-11-22T05:35:09
ER  -