TY  - JOUR
AB  - Ezrin, radixin, moesin, and merlin are cytoskeletal proteins, whose functions are specific to metazoans. They participate in cell cortex rearrangement, including cell–cell contact formation, and play an important role in cancer progression. Here, we have performed a comprehensive phylogenetic analysis of the proteins spanning 87 species. The results describe a possible mechanism for the protein family origin in the root of Metazoa, paralogs diversification in vertebrates, and acquisition of novel functions, including tumor suppression. In addition, a merlin paralog, present in most vertebrates but lost in mammals, has been described here for the first time. We have also highlighted a set of amino acid variations within the conserved motifs as the candidates for determining physiological differences between ERM paralogs.
AU  - Shabardina, Victoria
AU  - Kashima, Yukie
AU  - Suzuki, Yutaka
AU  - Makałowski, Wojciech
DA  - 2019-12-12
KW  - protein evolution
KW  - paralogs fate
KW  - ERM phylogeny
LA  - eng
N1  - Genome Biology and Evolution 12 (2020) 1, 3710-3724
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster)
PY  - 2019-12-12
TI  - Emergence and Evolution of ERM Proteins and Merlin in Metazoans
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-74079462184
Y2  - 2024-11-21T23:25:16
ER  -