TY  - JOUR
AB  - Objectives: Recent trials with craniospinal irradiation (CSI) via helical Tomotherapy (HT) demonstrated encouraging medulloblastoma results. In this study, we assess the toxicity profile of different radiation techniques and estimate survival rates. Materials and Methods: We reviewed the records of 46 patients who underwent irradiation for medulloblastoma between 1999 and 2019 (27 conventional radiotherapy technique (CRT) and 19 HT). Patient, tumor, and treatment characteristics, as well as treatment outcomes—local control rate (LCR), event-free survival (EFS), and overall survival (OS)—were reviewed. Acute and late adverse events (AEs) were evaluated according to the Radiation Therapy Oncology Group and the European Organization for Research and Treatment of Cancer (RTOG/EORTC) criteria. Results: In total, 43 courses of CSI and three local RT were administered to the 46 patients: 30 were male, the median age was 7 years (range 1–56). A median total RT dose of 55 Gy (range 44–68) and a median CSI dose of 35 Gy (range, 23.4–40) was delivered. During follow-up (median, 99 months), six patients (13%) developed recurrence. The EFS rate after 5 years was 84%. The overall OS rates after 5 and 10 years were 95% and 88%, respectively. There were no treatment-related deaths. Following HT, a trend towards lower grade 2/3 acute upper gastrointestinal (p = 0.07) and subacute CNS (p = 0.05) toxicity rates was detected compared to CRT-group. The risk of late CNS toxicities, mainly grade 2/3, was significantly lower following HT technique (p = 0.003). Conclusion: CSI via HT is an efficacious treatment modality in medulloblastoma patients. In all, we detected a reduced rate of several acute, subacute, and chronic toxicities following HT compared to CRT.
AU  - Öztunali, Anil
AU  - Elsayad, Khaled
AU  - Elsayad, Khaled Abdelsalam Mohamed Shahereldin
AU  - Scobioala, Sergiu
AU  - Channaoui, Mohammed
AU  - Haverkamp, Uwe
AU  - Haverkamp, U.
AU  - Grauer, Oliver Martin
AU  - Sträter, Dirk Ronald
AU  - Brentrup, Angela
AU  - Stummer, Walter
AU  - Kerl, Kornelius Tobias
AU  - Eich, Hans-Theodor
AU  - Eich, Hans Theodor
AU  - Eich, Hans Theodor
AU  - Eich, Hans Theodor
DA  - 2021-01-28
DO  - 10.17879/43039624533
KW  - conventional
KW  - Tomotherapy
KW  - intensity-modulated
KW  - toxicity
LA  - eng
N1  - Cancers 13 (2021) 3, 501, 1-12
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2021-01-28
TI  - Toxicity Reduction after Craniospinal Irradiation via Helical Tomotherapy in Patients with Medulloblastoma: A Unicentric Retrospective Analysis
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-23009756732
Y2  - 2024-11-22T05:22:46
ER  -