TY  - JOUR
AB  - Chronic hepatitis C can be treated very effectively with direct-acting antivirals (DAA) with only minor side effects compared to an interferon-containing treatment regimen. The significance of metabolic comorbidities after HCV cure is not well defined. This study aims to investigate short- and long-term weight change of patients receiving interferon-free antiviral treatment for chronic hepatitis C. The German Hepatitis C-registry (DHC-R) is a national multicenter real-world cohort. A total of 5111 patients were followed prospectively after DAA treatment for up to 3 years. Weight change compared to baseline was analyzed at end of treatment and at years 1, 2, and 3 after completion of antiviral therapy. Regression analysis was performed to identify baseline predictors for weight change. While there was no relevant mean weight change (−0.2 kg, SD 4.3 kg) at the end of antiviral treatment, weight started to increase during long-term follow-up reaching +1.7 kg (SD 8.0 kg, p < 0.001) compared to baseline at 3 years (follow-up year 3, FU3) after completion of antiviral therapy. 48%, 31%, and 22% of patients had a weight gain greater than 1, 3, and 5 kg at FU3, respectively. During follow-up, a body mass index (BMI) <30 proved to be the only consistent predictor for weight gain. DAA treatment is followed by a substantial weight gain (+3 kg or more) in one-third of the patients during long-term follow-up. Non-obese patients seemed to be most vulnerable to weight gain. The body compartment involved in weight gain as well as the mechanism of weight gain remain to be elucidated.
AU  - Schlevogt, Bernhard
AU  - Böker, Klaus H. W.
AU  - Böker, Klaus H.
AU  - Mauss, Stefan
AU  - Klinker, Hartwig
AU  - Heyne, Renate
AU  - Link, Ralph
AU  - Simon, Karl-Georg
AU  - Simon, K.-G.
AU  - Sarrazin, Christoph
AU  - Sarrazin, Christoph Michael
AU  - Serfert, Yvonne
AU  - Serfert, Y.
AU  - Manns, Michael P.
AU  - Manns, Michael Peter
AU  - Manns, P.
AU  - Manns, M. P.
AU  - Manns, Michael
AU  - Wedemeyer, Heiner
AU  - Wedemeyer, Hans Heinrich
AU  - Wedemeyer, Hans-Heinrich
AU  - Wedemeyer, H.
AU  - Wedemeyer, Johannes
AU  - Wedemeyer, Heins-Heinrich
DA  - 2021-10-19
DO  - 10.17879/42049553836
KW  - chronic hepatitis C
KW  - direct-acting antivirals
KW  - interferon-free
KW  - HCV cure
KW  - weight gain
KW  - German Hepatitis C-Registry
LA  - eng
N1  - Biomedicines 9 (2021) 10, 1495, 1-12
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2021-10-19
TI  - Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C—Results from the German Hepatitis C-Registry (DHC-R)
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-42049549921
Y2  - 2024-11-22T02:37:47
ER  -