TY  - JOUR
AB  - Aims: The European Senior Program (ESP) aims to avoid waiting list competition between younger and elderly patients applying for renal transplantation. By listing patients ≥65 years on a separate waiting list and locally allocating of grafts ≥65 years exclusively to this cohort, waiting and cold ischemia times are predicted to be shortened, potentially resulting in improved kidney transplantation outcomes. This study compared a historic cohort of renal transplant recipients being simultaneously listed on the general and the ESP waiting lists with a collective exclusively listed on the ESP list in terms of surrogates of the transplantation outcome. Methods: Total 151 eligible patients ≥ 65 years from Münster transplant Center, Germany, between 1999 and 2014 were included. Graft function, graft and patient survival were compared using surrogate markers of short- and long-term graft function. Patients were grouped according to their time of transplantation. Results: Recipients and donors in the newESP (nESP) cohort were significantly older (69.6 ± 3.5 years vs 67.1 ± 2 years, p<0.05; 72.0 ± 5.0 years vs 70.3 ± 5.0 years, p = 0.039), had significantly shorter dialysis vintage (19.6 ± 21.7 months vs 60.2 ± 28.1 months, p<0.001) and suffered from significantly more comorbidities (2.2 ± 0.9 vs 1.8 ± 0.8, p = 0.009) than the historic cohort (HC). Five-year death-censored graft survival was better than in the HC, but 5-year graft and patient survival were better in the ESP cohort. After 2005, cold ischemia time between groups was comparable. nESP grafts showed more primary function and significantly better long-term graft function 18 months after transplantation and onwards. Conclusion: nESP recipients received significantly older grafts, but experienced significantly shorter time on dialysis. Cold ischemia times were comparable, but graft function in the nESP cohort was significantly better in the long term.
AU  - Mehdorn, Anne-Sophie
AU  - Reuter, Stefan Johannes
AU  - Suwelack, Barbara
AU  - Schütte-Nütgen, Katharina
AU  - Becker, Felix
AU  - Senninger, Norbert
AU  - Palmes, Daniel Michael
AU  - Vogel, Thomas
AU  - Bahde, Ralf
DA  - 2020-07-23
DO  - 10.17879/24049618455
KW  - Graft survival
KW  - Medical dialysis
KW  - Renal transplantation
KW  - Creatinine
KW  - Diabetes mellitus
KW  - Ischemia
KW  - Surgical and invasive medical procedures
KW  - Geriatric care
LA  - eng
N1  - PLoS ONE 15 (2020) 7, e0235680, 1-16
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2020-07-23
TI  - Comparison of kidney allograft survival in the Eurotransplant senior program after changing the allocation criteria in 2010—A single center experience
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-24049617350
Y2  - 2024-11-22T03:28:11
ER  -