TY  - JOUR
AB  - The human cortex is characterized by local morphological features such as cortical thickness, myelin content, and gene expression that change along the posterior-anterior axis. We investigated if some of these structural gradients are associated with a similar gradient in a prominent feature of brain activity - namely the frequency of oscillations. In resting-state MEG recordings from healthy participants (N = 187) using mixed effect models, we found that the dominant peak frequency in a brain area decreases significantly along the posterior-anterior axis following the global hierarchy from early sensory to higher order areas. This spatial gradient of peak frequency was significantly anticorrelated with that of cortical thickness, representing a proxy of the cortical hierarchical level. This result indicates that the dominant frequency changes systematically and globally along the spatial and hierarchical gradients and establishes a new structure-function relationship pertaining to brain oscillations as a core organization that may underlie hierarchical specialization in the brain.
AU  - Mahjoory, Keyvan
AU  - Schoffelen, Jan-Mathijs
AU  - Keitel, Anne
AU  - Gross, Joachim
DA  - 2020-08-21
DO  - 10.17879/14029477916
KW  - Research Article
KW  - Neuroscience
KW  - brain oscillations
KW  - peak frequency
KW  - MEG
KW  - structure-function relationship in brain
KW  - cortical hierarchy
KW  - cortical thickness
LA  - eng
N1  - eLife 9 (2020), e53715, 1-18
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2020-08-21
TI  - The frequency gradient of human resting-state brain oscillations follows cortical hierarchies
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-44019490353
Y2  - 2024-11-22T05:54:22
ER  -