TY  - JOUR
AB  - We present the case of a 55-year-old female patient with metamizole-induced agranulocytosis after total knee arthroplasty, leading to septic periprosthetic joint infections (PJIs). Owing to metamizole-induced agranulocytosis, the synovial leukocyte count was negative. Here, we discuss the diagnostic challenges evolving from sepsis and neutropenia in patients with suspected PJIs. We suggest an urgent surgical approach, mainly focusing on the clinical presentation preoperatively. Later, our patient developed candidemia and periprosthetic tissue samples were positive for Candida albicans. For fungal PJIs, long-term follow-up studies are lacking and therapeutic recommendations differ. Here, we present our therapeutic approach, including staged revision and 12 weeks of systemic antifungal therapy, and discuss recent findings regarding the therapy of fungal PJIs.
AU  - Oenning, Sebastian
AU  - Möllenbeck, Burkhard H. M.
AU  - Gosheger, Georg
AU  - Schmidt-Bräkling, Tom
AU  - Schwarze, Jan
AU  - Ackmann, Thomas
AU  - Schneider, Kristian Nikolaus
AU  - Theil, Jan-Christoph
DA  - 2020-08-27
DO  - 10.17879/34079451075
KW  - Periprosthetic infection
KW  - Agranulocytosis
KW  - Fungal infection
KW  - Candida infection
KW  - Total knee arthroplasty
KW  - Revision arthroplasty
LA  - eng
N1  - Arthroplasty Today 6 (2020) 4, 726-730
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2020-08-27
TI  - Fungal Periprosthetic Knee Joint Infection in a Patient with Metamizole-Induced Agranulocytosis
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-14049575279
Y2  - 2024-11-22T06:40:49
ER  -