TY  - JOUR
AB  - Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor immunity and tumor stromal cells. The cell membrane and integral membrane proteins commonly act as important sensors and transducers of altered pH. Cell adhesion molecules and cation channels are prominent membrane proteins, the majority of which is regulated by protons. The pathophysiological consequences of proton-sensitive ion channel function in cancer, however, are scarcely considered in the literature. Thus, the main focus of this review is to highlight possible events in tumor progression and tumor immunity where the pH sensitivity of cation channels could be of great importance.
AU  - Pethő, Zoltán
AU  - Najder, Karolina
AU  - Carvalho, Tiago
AU  - McMorrow, Roisin
AU  - Todesca, Luca Matteo
AU  - Rugi, Micol
AU  - Bulk, Etmar Michael
AU  - Chan, Alan
AU  - Löwik, Clemens W. G. M.
AU  - Reshkin, Stephan J.
AU  - Schwab, Albrecht
DA  - 2020-09-02
DO  - 10.17879/44079418354
KW  - ion channel
KW  - membrane potential
KW  - tumor immunity
KW  - pH homeostasis
KW  - protonation
KW  - cancer physiology
KW  - tumor microenvironment
KW  - cell adhesion molecules
LA  - eng
N1  - Cancers 12 (2020) 9, 2484, 1-37
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
N1  - Förderer: European Commission / Projektnummer: H2020-MSCA-ITN-2018
N1  - Funding organisation: European Commission / Project number: H2020-MSCA-ITN-2018
PY  - 2020-09-02
TI  - pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-14049480132
Y2  - 2024-11-22T05:11:15
ER  -