TY  - JOUR
AB  - Respiratory infections with newly emerging zoonotic viruses such as SARS-CoV-2, the etiological agent of COVID-19, often lead to the perturbation of the human innate and adaptive immune responses causing severe disease with high mortality. The responsible mechanisms are commonly virus-specific and often include either over-activated or delayed local interferon responses, which facilitate efficient viral replication in the primary target organ, systemic viral spread, and rapid onset of organ-specific and harmful inflammatory responses. Despite the distinct replication strategies, human infections with SARS-CoV-2 and highly pathogenic avian influenza viruses demonstrate remarkable similarities and differences regarding the mechanisms of immune induction, disease dynamics, as well as the long-term sequelae, which will be discussed in this review. In addition, we will highlight some important lessons about the effectiveness of antiviral and immunomodulatory therapeutic strategies that this pandemic has taught us.
AU  - Faist, Aileen
AU  - Janowski, Josua
AU  - Kumar, Sriram
AU  - Hinse, Saskia
AU  - Çalışkan, Duygu Merve
AU  - Lange, Julius
AU  - Ludwig, Stephan
AU  - Brunotte, Linda
DA  - 2022-07-14
DO  - 10.17879/12099501681
KW  - Systemische Entzündung
KW  - Virusinfektion
KW  - COVID-19
KW  - hochpathogene aviäre Influenzaviren
KW  - Immunantwort
KW  - systemic inflammation
KW  - viral infection
KW  - highly pathogenic avian influenza
KW  - immune response
LA  - eng
N1  - Cells 11 (2022) 14, 2198, 1-31
N1  - Förderer: Deutsche Forschungsgemeinschaft / Projektnummer: 414847370
N1  - Funding organisation: Deutsche Forschungsgemeinschaft / Project number: 414847370
PY  - 2022-07-14
TI  - Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-12099492019
Y2  - 2024-11-24T18:16:37
ER  -