TY  - JOUR
AB  - There is conflicting evidence regarding the impact of propofol on cardiac repolarization and the risk of torsade de pointes (TdP). The purpose of this study was to elucidate the risk of propofol-induced TdP and to investigate the impact of propofol in drug-induced long QT syndrome. 35 rabbit hearts were perfused employing a Langendorff-setup. 10 hearts were perfused with increasing concentrations of propofol (50, 75, 100 µM). Propofol abbreviated action potential duration (APD90) in a concentration-dependent manner without altering spatial dispersion of repolarization (SDR). Consequently, no proarrhythmic effects of propofol were observed. In 12 further hearts, erythromycin was employed to induce prolongation of cardiac repolarization. Erythromycin led to an amplification of SDR and triggered 36 episodes of TdP. Additional infusion of propofol abbreviated repolarization and reduced SDR. No episodes of TdP were observed with propofol. Similarly, ondansetron prolonged cardiac repolarization in another 13 hearts. SDR was increased and 36 episodes of TdP occurred. With additional propofol infusion, repolarization was abbreviated, SDR reduced and triggered activity abolished. In this experimental whole-heart study, propofol abbreviated repolarization without triggering TdP. On the contrary, propofol reversed prolongation of repolarization caused by erythromycin or ondansetron, reduced SDR and thereby eliminated drug-induced TdP.
AU  - Ellermann, Christian
AU  - Könemann, Hilke Maren
AU  - Wolfes, Julian
AU  - Rath, Benjamin
AU  - Wegner, Felix K.
AU  - Willy, Kevin Kurt
AU  - Dechering, Dirk G.
AU  - Reinke, Florian Johann
AU  - Eckardt, Lars
AU  - Frommeyer, Gerrit
DA  - 2020-07-22
DO  - 10.17879/24049728813
KW  - Cardiovascular biology
KW  - Experimental models of disease
KW  - Preclinical research
KW  - Risk factors
KW  - Translational research
LA  - eng
N1  - Scientific Reports 10 (2020) 12133, 1-9
N1  - Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
PY  - 2020-07-22
TI  - Propofol abolishes torsade de pointes in different models of acquired long QT syndrome
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-24049662181
Y2  - 2024-11-22T03:03:37
ER  -