TY  - JOUR
AB  - Low-molecular-weight polyamines such as spermine and spermidine are ubiquitous in all forms of life and are involved in many cellular functions such as cell growth. Pathological altered polyamine concentration are associated with a variety of diseases. We thus aimed for their analysis from serum using reversed-phase liquid chromatography coupled to detection with quadrupole time-of-flight mass spectrometry. We tested 15 polyamines for their response, developed a multiplex target method, and refined it for five active substances including spermine and spermidine, which induced expression of the autophagy protein Atg8/LC3-II in a neuronal cell line.
AU  - Smollich, Joachim
AU  - McLaughlin, Calum
AU  - Gilmour, Ryan
AU  - Lünemann, Jan
AU  - König, Simone
DA  - 2022
DO  - 10.17879/04069541302
KW  - Polyamine, Q-TOF, Spermin, Spermidin
KW  - Polyamines, Q-TOF, spermine, spermidine
LA  - eng
IS  - Mercator Journal of Biomolecular Analysis
M2  - 1
PY  - 2022
SP  - 1-5
T2  - Mercator Journal of Biomolecular Analysis
TI  - Target analysis of underivatized biogenic amines with reversed-phase chromatography and quadrupole time-of-flight mass spectrometry
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:6-04069535712
Y2  - 2024-11-24T02:38:21
ER  -