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Titelaufnahme

  • Titel
    Alignment- and reference-free phylogenomics with colored de-Bruijn graphs
  • Verfasser
    Wittler, Roland
  • Erschienen
    2019
  • Sprache
    Englisch
  • Dokumenttyp
    Vorabdruck
  • URN
    urn:nbn:de:0070-pub-29356042 
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Abstract
  • We present a new whole-genome based approach to infer large-scale phylogenies
    that is alignment- and reference-free. In contrast to other methods, it does
    not rely on pairwise comparisons to determine distances to infer edges in a
    tree. Instead, a colored de-Bruijn graph is constructed, and information on
    common subsequences is extracted to infer phylogenetic splits. Application to
    different datasets confirms robustness of the approach. A comparison to other
    state-of-the-art whole-genome based methods indicates comparable or higher
    accuracy and efficiency.
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