Inspired by the path followed by Matthias Ballauff over the past 20 years, the development of thermosensitive core-shell microgel structures is reviewed. Different chemical structures, from hard nanoparticle cores to double stimuli-responsive microgels have been devised and successfully implemented by many different groups. Some of the rich variety of these systems is presented, as well as some recent progress in structural analysis of such microstructures by small-angle scattering of neutrons or X-rays, including modelling approaches. In the last part, again following early work by the group of Matthias Ballauff, applications with particular emphasis on incorporation of catalytic nanoparticles inside core-shell structures-stabilising the nanoparticles and granting external control over activity-will be discussed, as well as core-shell microgels at interfaces.