In Vitro Assembly of Virus-Like Particles and Their Applications

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Titel
In Vitro Assembly of Virus-Like Particles and Their Applications
Verfasser
Le, Dinh To ; Müller, Kristian
Enthalten in
Life, Jg. 11 H. 4
Erschienen
2021
Sprache
Englisch
Dokumenttyp
Aufsatz in einer Zeitschrift
Schlagwörter
capsid protein / in vitro assembly / virus-like particle / VLP-based vaccines / drug delivery
URN
urn:nbn:de:0070-pub-29540655
DOI
10.3390/life11040334

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Abstract

Virus-like particles (VLPs) are increasingly used for vaccine development and drug delivery. Assembly of VLPs from purified monomers in a chemically defined reaction is advantageous compared to in vivo assembly, because it avoids encapsidation of host-derived components and enables loading with added cargoes. This review provides an overview of ex cella VLP production methods focusing on capsid protein production, factors that impact the in vitro assembly, and approaches to characterize in vitro VLPs. The uses of in vitro produced VLPs as vaccines and for therapeutic delivery are also reported.

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