Dynamics and interplay among various drivers and competencies in any organizational set-up shape the configurations of the systems black box. Structural flexibility, information management, decision making and leadership are critical components which manage the intra-organizational interactions for a collective meaningful outcome in terms of organizational change capability and superior performance. In the recent past, the Indian pharmaceutical sector has witnessed impressive global consolidation and expansion. The organizational health recipes which have been designed by the Indian pharmaceutical sector for its healthy growth need to be explored and understood. Identifying how these variables interact and how they have contributed to the success of the pharmaceutical sector is the key research agenda of this paper. The responses obtained from 216 mid- and senior-level executives of the Indian pharmaceutical industry have been processed by structural equation modeling to investigate interactive dynamics. Therefore, the outcomes are of value to scholars as well as practitioners.