In this paper are shown the main trends for the use of propolis based on the patent or invention documents. Information is given on the owners, innovators, international patent classification, subject groups and priority countries. The obtained results show that propolis is a natural product of interest for the current technological and scientific world, since the innovation capability has been kept in the subjects studied in this work. There is remarkable work on the application of propolis for treatment and care of skin. Japan is known to be the leading country in the use of propolis in health care.